These scales can be roughly categorized as microscale, mesoscale and macroscale. In 2012, Seung published the book Connectome: How the Brain's Wiring Makes Us Who We Are.Д«rain networks can be defined at different levels of scale, corresponding to levels of spatial resolution in brain imaging (KГ¶tter, 2007, Sporns, 2010). The term 'connectome' was more recently popularized by Sebastian Seung's I am my Connectome speech given at the 2010 TED conference, which discusses the high-level goals of mapping the human connectome, as well as ongoing efforts to build a three-dimensional neural map of brain tissue at the microscale.

In a similar manner, one could consider the brain connectome, set of all neuronal connections, as one single entity, thus emphasizing the fact that the huge brain neuronal communication capacity and computational power critically relies on this subtle and incredibly complex connectivity architecture. The genome is an entity it-self, as it is from the subtle gene interaction that emerges. It is clear that, like the genome, which is much more than just a juxtaposition of genes, the set of all neuronal connections in the brain is much more than the sum of their individual components. thesis, From diffusion MRI to brain connectomics, Hagmann wrote: The connectome will significantly increase our understanding of how functional brain states emerge from their underlying structural substrate, and will provide new mechanistic insights into how brain function is affected if this structural substrate is disrupted. We propose to call this dataset the human 'connectome,' and we argue that it is fundamentally important in cognitive neuroscience and neuropsychology. The purpose of this article is to discuss research strategies aimed at a comprehensive structural description of the network of elements and connections forming the human brain. To understand the functioning of a network, one must know its elements and their interconnections. In their 2005 paper, 'The Human Connectome, a structural description of the human brain', Sporns et al. 'Connectomics' (Hagmann, 2005) has been defined as the science concerned with assembling and analyzing connectome data sets. This term was directly inspired by the ongoing effort to sequence the human genetic code-to build a genome. Patric Hagmann at Lausanne University Hospital independently and simultaneously suggested the term 'connectome' to refer to a map of the neural connections within the brain.

Olaf Sporns at Indiana University and Dr. 2.3.2 Challenge for macroscale connectomics.2.3.1 Recent advances in connectivity mapping.

Indeed, the foundation of human cognition lies in the pattern of dynamic interactions shaped by the connectome.Дespite such complex and variable structure-function mappings, the connectome is an indispensable basis for the mechanistic interpretation of dynamic brain data, from single-cell recordings to functional neuroimaging. There are strong natural constraints on which neurons or neural populations can interact, or how strong or direct their interactions are. The significance of the connectome stems from the realization that the structure and function of the human brain are intricately linked, through multiple levels and modes of brain connectivity. A connectome is constructed by tracing the neuron in a nervous system and mapping where neurons are connected through synapses. An organism's nervous system is made up of neurons which communicate through synapses. ДЄ connectome ( / k Й™ Л€ n Й› k t oКЉ m/) is a comprehensive map of neural connections in the brain, and may be thought of as its ' wiring diagram'. Visualization of fibers was done using TrackVis software. Anatomical fibers that constitute the white matter architecture of the human brain are visualized color-coded by traversing direction (xyz-directions mapping to RGB colors respectively). Rendering of a group connectome based on 20 subjects.

What is white matter in the brain